Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis

Thermal and Non-thermal Plasmas in the Galaxy Cluster 3C 129

We describe new Chandra spectroscopy data of the cluster which harbors the prototypical "head tail" radio galaxy 3C 129 and the weaker radio galaxy 3C 129.1. We combined the Chandra data with Very Large Array (VLA) radio data taken at 0.33, 5, and 8 GHz (archival data) and 1.4 GHz (new data). We also obtained new HI observations at the Dominion Radio Astrophysical Observatory (DRAO) to measure the neutral Hydrogen column density in the direction of the cluster with arcminute angular resolution. The Chandra observation reveals extended X-ray emission from the radio galaxy 3C 129.1 with a total luminosity of 1.5E+41 erg/s. The X-ray excess is resolved into an extended central source of ~2 arcsec (1 kpc) diameter and several point sources with an individual luminosity up to 2.1E+40 erg/s. In the case of the radio galaxy 3C 129, the Chandra observation shows, in addition to core and jet X-ray emission reported in an earlier paper, some evidence for extended, diffuse X-ray emission from a region east of the radio core. The 12 arcsec x 36 arcsec (6 kpc x 17 kpc) region lies "in front" of the radio core, in the same direction into which the radio galaxy is moving. We use the radio and X-ray data to study in detail the pressure balance between the non-thermal radio plasma and the thermal Intra Cluster Medium (ICM) along the tail of 3C 129 which extends over 15 arcmin (427 kpc). Depending on the assumed lower energy cutoff of the electron energy spectrum, the minimum pressure of the radio plasma lies a factor of between 10 and 40 below the ICM pressure for a large part of the tail. We discuss several possibilities to explain the apparent pressure mismatch.Comment: Accepted for publication in MNRAS. Refereed manuscript. 14 pages, 8 figures, additional panel of Fig. 3 shows asymmetric ICM distributio

Symmetry planes of Paleozoic crinoids

2 p., 1 fig.http://paleo.ku.edu/contributions.htm

Additional Permian crinoids from southern Nevada

32 p., 8 pl., 4 fig.http://paleo.ku.edu/contributions.htm

Crinoids from the Anchor Limestone (Lower Mississippian) of the Monte Cristo Group, southern Nevada

56 p., 12 fig.http://paleo.ku.edu/contributions.htm

Prime: A framework for co-located multi-device apps

Even though mobile devices are ubiquitous, the conceptually simple endeavor of using co-located devices for multi-user experiences is cumbersome. It may not even be possible when certain apps are not widely available. We introduce Prime, a thin-client framework for colocated multi-device apps (MDAs). It leverages wellestablished remote display protocols to enable spontaneous use of MDAs. One device acts as a host, executing the app on behalf of connected clients. The key challenges is dynamic scalability: providing high framerates, low latency and fairness across clients. Therefore, we have developed: An online scheduling algorithm that provides frame rate, latency and fairness guarantees; a modified 802.11 MAC protocol that provides low-latency and fairness; and an efficient video encoder pipeline that offers up to fourteen times higher framerates. We show that Prime can scale a host up to seven concurrent players for a commercially released open source action game, achieving touch-To-pixel latency below 100ms for all clients

Non-genetic inheritance, fertility and assisted reproductive technologies

The concept of non-genetic inheritance is gaining considerable attention in the assisted reproductive technology (ART) community due to the reported differences between children born from ART and those that are conceived naturally. It has been demonstrated that children conceived via ART have differences in fetal growth, birth weight, congenital abnormalities, cardiometabolic parameters, glucose homeostasis as well as changes to body composition compared to children conceived naturally. Although these changes may have a parental contribution and may be influenced by the pathology of infertility there is concern that the technologies themselves may play a role. In support of this, is emerging evidence that aspects of ART technology such as culture media formulation and insemination method can alter offspring phenotype. In addition it is also documented that exposure to environmental factors, such as toxins can impact on offspring gametogenesis such that these perturbations persist through generations. With the increasing use of ART and the development of new technologies it is vital that we understand whether ART can effect non-genetic inheritance so that we can optimise technology and prevent abnormal programming and its impact on all aspects of offspring health including fertility and a possible transmission to subsequent generations.Deirdre Zander-Fox, Nicole O McPherson, Michelle Lan

Pairing and alpha-like quartet condensation in N=Z nuclei

We discuss the treatment of isovector pairing by an alpha-like quartet condensate which conserves exactly the particle number, the spin and the isospin. The results show that the quartet condensate describes accurately the isovector pairing correlations in the ground state of systems with an equal number of protons and neutronsComment: 4 pages, to appear in Journal of Physics: Conference Serie